Investigation of the Potential Bioeffects from Diagnostic Ultrasound Exposure in Rat Lungs

Recent increases in the pressure output of diagnostic ultrasound scanners have led to an interest in establishing thresholds for bioeffects in many organs including the lungs of mammals. Damage may be mediated by inertial cavitation, yet there have been no such direct observations in vivo. To explore the hypothesis of cavitation-based bioeffects from diagnostic ultrasound, research has been performed on the thresholds of damage in ratlungs exposed to 4.0-MHz pulsed Doppler and color Doppler ultrasound. A 30-MHz active cavitation detection scheme complementing these studies provides the first direct evidence of cavitation in vivo from diagnostic ultrasound pulses.

Related References:

Holland al. 1996, Ultrasound in Medicine and Biology, 22:917-925

Alignment of 30 MHz Active Cavitation Detector with ATL L10-5 scanhead.

Active Cavitation Detector Electronics.

Histopathology of petechial hemorrhage in rat lung exposed to 6 MHz Doppler Pulse for 1.5 minutes at MI=1.5.

Histopathology of normal rat lung.